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Sex-Specific Behavioral and Molecular Responses to Maternal Lipopolysaccharide-Induced Immune Activation in a Murine Model: Implications for Neurodevelopmental Disorders

Optimizing stem cell infusion timing in the prevention of acute graft-versus-host disease

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a cornerstone treatment for a broad spectrum of malignant and nonmalignant hematological disorders. However, the success of allo-HSCT is often overshadowed by acute graft-versus-host disease (aGVHD), a life-threatening complication. Here, we show in patients and murine models that the circadian timing of stem cell infusion dictates the development of aGVHD. Early-infused patients exhibit a significantly lower incidence and severity of aGVHD, as well as improved survival. We observed time-of-day variations in the levels of cytokines, especially IL-1α, which controls donor T cell responses after transplantation. The levels of IL-1α in patients were strongly associated with the development of aGVHD. Furthermore, preclinical results showed that the administration of IL-1α neutralizing antibodies markedly alleviated aGVHD and increased survival. Our study suggests that scheduling stem cell infusions early in the day could be a simple yet transformative intervention for preventing aGVHD.

Macrophage-Hosted Porphyromonas gingivalis Is a Risk Factor for Cataract Development

【备加速】乐备实助力炎症性肠病的潜在药物研究

The triple combination DBDx alleviates cytokine storm and related lung injury

Macrophage STING signaling promotes fibrosis in benign airway stenosis via an IL6- STAT3 pathway

TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors

LabEx Luminex平台助力探索肿瘤治疗SIRPα阻断免疫治疗中联合靶向IL-6的效果

本周为大家带来的文献为发表于Biochem Biophys Res Commun.的” SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer”。本文使用了LabEx提供的Luminex检测服务。

LabEx CBA平台助力血吸虫生殖机制研究

本周为大家带来的文献为发表于Int J Parasitol.（IF：3.7）的” Schistosoma japonicum translationally controlled tumour protein, which is associated with the development of female worms, as a target for control of schistosomiasis”。本文使用了LabEx提供的CBA检测服务。

LabEx抗体芯片平台助力探索ELFN1-AS1是否调控结直肠癌中的免疫监视

本周为大家带来的文献为发表于Discov Oncol.（IF：2.8）的” ELFN1-AS1 promotes GDF15-mediated immune escape of colorectal cancer from NK cells by facilitating GCN5 and SND1 association”。本文使用了LabEx提供的抗体芯片检测服务。