DSP人空间蛋白组图谱_570蛋白_72
15 Lipoxygenase 1,15-PGDH,2B4,5 Lipoxygenase/5-LO,ACE2,Actin,active YAP1,Adenosine Receptor A2a,AIF,AKR1B10,AKT1 (phospho S473),AKT1 (phospho T450),AKT3 + AKT2 + AKT1,ALDH1A1,Aldolase,Aldolase B+Aldolase C,ALK,alpha smooth muscle Actin,AMPK alpha 1,Androgen Receptor,APC,APG5L/ATG5,Argonaute-2,ARID1A,ARID3A,ASS1,ATF2,ATF3,ATG12,ATG7,ATM,ATM (phospho S1981),ATR (phospho S428),Aurora A,Axl,Bad,Bak,Bax,Bcl-2,Bcl6,Bcl-XL,Beclin 1,beta 2 Microglobulin,beta Actin,beta Arrestin 1,beta Catenin,beta glucuronidase (GUSB),beta Tubulin,BFL-1/GRS,Bid,Bim,BRAF,BRCA1,Brd4,BRG1,BTK,C Reactive Protein,C4a,C5 / C5b,Carbonic Anhydrase 3/CA3,Carbonic Anhydrase 9/CA9,Caspase-10/CASP-10,Caspase-3,Caspase-3 p12,Catalase,Cathepsin G,Cathepsin K,Cathepsin S,Caveolin-1,CCL18,CCR3,CCR5,CCR6,CCR7,CD103,CD11a,CD11b,CD11c,CD127,CD133,CD134 / OX40L receptor,CD14,CD15,CD16,CD163,CD177,CD18,CD20,CD22,CD27,CD272/BTLA,CD276,CD28,CD3 epsilon,CD31,CD33,CD34,CD36,CD38,CD39,CD3D,CD3G,CD4,CD40,CD40 Ligand,CD44,CD44v6,CD45,CD45RA,CD47,CD63,CD64,CD66b,CD68,CD70,CD73,CD74,CD79a,CD79b,CD8 alpha,CD83,CD86,CD90 / Thy1,CD94,CD99,CDK1,CDK1 (phospho T161) + CDK2 / CDK3 (phospho T160),CDK1 + Cdk2 + Cdk3 (phospho T14),CDK1 + CDK2 + CDK3 + CDK5 (phospho Y15),Cdk2,Cdk4,Cdk6,CDKN2A/p14ARF,CDKN2A/p16INK4a,c-Fos,Chk1,Chk2,cIAP2,c-Jun,c-Jun (phospho S63),c-Kit,Cleaved PARP1,c-Maf,c-Myb (phospho S11),c-Myc,c-Myc (phospho S62),Collagen I,Collagen IV,COX2 / Cyclooxygenase 2,CPT1A,CREB,CREB (phospho S133),CREBBP,CSF-1-R,CTLA4,Cullin 1/CUL-1,CXCL10/IP-10,CXCL5 + CXCL6,CXCR3,CXCR4,CXCR5,CXCR6,Cyclin A2,Cyclin B1,Cyclin D1,Cyclin E1,Cyclin E2,Cyclophilin A,Cytokeratin 1,Cytokeratin 14,Cytokeratin 17,Cytokeratin 19,Cytokeratin 5,Cytokeratin 8,Cytokeratin 8 (phospho S431),Dihydrofolate reductase (DHFR),Dnmt1,DR5,DUSP6,E Cadherin,EGFR,EGFR (phospho Y1068),EMR1/ADGRE1,ENO1 + ENO2 + ENO3,eNOS,EpCAM,ErbB2 / HER2,ErbB2 / HER2 (phospho Y877),ErbB3 / HER3,ErbB4 / HER4 (phospho Y1162),ErbB4 / HER4+ErbB2 / HER2,ERG,ERK1,ERK1 (phospho T202 + Y204) + ERK2 (phospho T185 + Y187),ERK1 (phospho T202) + ERK2 (phospho T185),ERK2,Estrogen Receptor alpha,ETS1,FABP4,FADD,FAK,FANCI,Fas,Fatty Acid Synthase,FBP2,FGF2,FGFR2,Fibronectin,Fos B,FOXO1A,FOXO4/AFX,FOXP3,Galectin 3,gamma H2A.X (phospho S139),GATA3,GGT1/GGT,GITR,GLB1/Beta-galactosidase,GLP-1,GLP-1R,Glucocorticoid Receptor (phospho S226),Glucose 6 Phosphate Dehydrogenase,Glucose Transporter GLUT1,Glutaminase,Glutathione Peroxidase 4,GNLY/Granulysin,Granzyme A,Granzyme B,Granzyme K,GRP78 BiP,GSK3 beta,GSK3 beta (phospho S9),HDAC1,HDAC2,HDAC3,HDAC4 + 5 + 9,HDAC6,HDAC9,Heme Oxygenase 1,Hexokinase 1,Hexokinase II,HIF-1 alpha,Histone H2A (acetyl K5),Histone H2A (phospho T120),Histone H2A.X,Histone H2B (acetyl K5),Histone H3 (acetyl K14),Histone H3 (acetyl K18),Histone H3 (acetyl K27),Histone H3 (acetyl K9),Histone H3 (di methyl K4),Histone H3 (di methyl K79),Histone H3 (mono methyl K4),Histone H3 (phospho S10),Histone H3 (phospho S28),Histone H3 (tri methyl K27),Histone H3 (tri methyl K36),Histone H3 (tri methyl K9),HLA A,HLA B7,HLA E,HLA F,HLA G,HLA-C,HLA-DPB1,HLA-DR,HMGB1,HMGB2,Hsp27,Hsp27 (phospho S78),Hsp70,Hsp90,HuR / ELAVL1,ICAM1,ICOS,IDH1,IDH2,IFIT1,IFNGR1,IGF1 Receptor,IGF2BP1/IMP1,Ikaros,IKB alpha,IKK alpha,IKK beta,IKK gamma/NEMO,IKKi/IKKe,IL-1 alpha,IL-1 beta,IL-12A,IL-12RB1,IL-15RA,IL-18,IL-1RA,IL-2 Receptor alpha,IL22 RA2/IL-22BP,IL-22RA1,IL-2RG,IL-33,IL3RA/CD123,IL4,IL-5RA,IL-6R,IMP3,Indoleamine 2, 3-dioxygenase,iNOS,Insulin,Insulin Receptor alpha,Insulin Receptor beta,Integrin alpha 5,Integrin alpha 6,Integrin beta 1,Interferon gamma,IRF3,IRF4,IRF5,ISG15,JAK3,JNK1 + JNK2 + JNK3 (phospho T183+T183+T221),JunD,KDM3A / JHDM2A,Ki67,KIR2DL1 + KIR2DL2,KIR2DL3,KIR3DL1 + KIR3DS1,KMT6 / EZH2,KMT6/EZH2 (phospho T487),Lactate Dehydrogenase,LAG-3,Lamin A + Lamin B1 + Lamin C,LAMP1,LAMP2A,LC3B,Lck,LDL Receptor,LEF1,LILRB3,Liver Arginase,LYVE1,Macrophage Inflammatory Protein 1 alpha / CCL3,Macrophage Inflammatory Protein 3 alpha,Mannose Receptor,M-CSF,MDM2 (phospho S166),MEK1,MEK1 (phospho S298),MEK2,MEK4/MKK4 (phospho S80),MEKK3,MelanA,Melanoma gp100,Met (c-Met),Met (c-Met) (phospho Y1349),MICA + MICB,MLH1,MMP1,MMP14,MMP3,MMP7,MMP8,MMP9,Monoamine Oxidase A/MAO-A,MRP8,MS4A2,MSH2,MSH6,mTOR,mTOR (phospho S2448),MUC1,Mucin 5AC,Musashi 1 / Msi1,MX1,MyD88,Myeloperoxidase,N Cadherin,NAK/TBK1,Nanog,NCAM1,NCR1,Nectin 2,Nectin-4,Neutrophil Elastase,NFAT2,NFkB p105 / p50,NF-kB p65,NKG2A + NKG2E + NKG2C,NKG2D,Notch1,NQO1,NRF1,NSD3,Occludin,Oct-2,Oct4,Osteopontin,p27 KIP 1,p27 KIP 1 (phospho S10),p38 (phospho T180),p38 beta/MAPK11 + p38 alpha/MAPK14,p40 - DeltaNp63,p53,p53 (acetyl K373),p53 (phospho S392),p53 (phospho S46),p57 Kip2,p63,p73,PAK1,PAK1+PAK2+PAK3 (phospho S141 + S144 + S154),pan Cytokeratin,Pan Trk,PARP1,PCNA,PD1,PDGF B,PDGFR alpha,PDGFR alpha + PDGFR beta,PD-L1,PD-L2,Periostin,PF4,PI 3 Kinase catalytic subunit alpha/PIK3CA,PI 3 Kinase catalytic subunit gamma/PI3K-gamma,PI 3 Kinase p85 alpha,PI 3 Kinase p85 beta,PKC beta 1,PLCG 2,Podoplanin / gp36,Poliovirus Receptor/PVR,PP2A alpha + beta,PRAME,PRAS40,PRDM1/Blimp1,Pro Caspase-8,Progesterone Receptor,Progesterone Receptor (phospho S190),Prostate Specific Antigen,PSMA,PTCH2,PTEN,PTEN (phospho T366),PTGES2/Gbf1,PU.1/Spi1,Rad51,RAGE,Raptor,Ras,Rb,Rb (phospho S608),Rb (phospho S807),Rb (phospho T252),Rb (phospho T356),Rb (phospho T373),Rb (phospho T780),Rel B,Ret,Retinoic Acid Receptor beta,Rho,Rho A + B + C,ROCK1,ROCK2 + ROCK1,ROS1,RPS6 (phospho S235 + S236),RPS6 (phospho S240 + S244),RSK1 p90,RSK1 p90 (phospho T359),RUNX1 / AML1 + RUNX3 + RUNX2,S100 beta,S100A12/CGRP,S100A4,S100A8 + S100A9,S100A9,S100P,S6K1,Scavenging Receptor SR-BI,SCF,SDHA,SFRP1,SFRP4,SHP1,SHP2,SIGLEC5,SIRT1,SIRT1 (phospho S47),SIRT2,SIRT3,SLC7A5/LAT1,Smac/Diablo,SMAD1 + SMAD5 + SMAD9 (phospho S463 + S465 + S467),Smad2,Smad2 (phospho S255),Smad2 (phospho S467),Smad3,Smad3 (phospho S423 + S425),Smad4,SMAD5,SOCS3,SOD2/MnSOD,SOD2/MnSOD (acetyl K68),Somatostatin Receptor 2,Sonic Hedgehog,SOX9,SQSTM1 / p62,Src,ST2,STAT1,STAT1 (phospho S727),STAT2,STAT3,STAT3 (phospho Y705),STAT5 (phospho Y694),STAT5a,STAT5b,STAT6,STAT6 (phospho Y641),STING,Sumo 1,Survivin,Syk,Syk (phospho Y323),Syk (phospho Y352) +ZAP70 (phospho Y319),Syndecan-1,TAK1,TAP2,T-bet / Tbx21,TBR2 / Eomes,TEF1/TEAD-1,TGF beta 1,Thymidylate Synthase,TIM 3,Tissue Factor,TLR7,TLR8,TLR9,TMPRSS2,TMS1/ASC,TNF alpha,TNFAIP3,Topoisomerase I,Topoisomerase II alpha,Topoisomerase II alpha (phospho S1106),Topoisomerase II alpha (phospho T1343),TRAF1,TRAF2,TRAF6,Transferrin Receptor,TROP2,Tuberin,Tuberin (phospho S1254),Tuberin (phospho T1462),UBE2C,Ubiquitin,uPA Receptor/U-PAR,Urokinase,VCAM1,VEGF Receptor 1,VEGF Receptor 2,VEGFA,VEGFD,Vimentin,VISTA,Von Willebrand Factor,Wee1,Wee1 (phospho S642),Wilms Tumor Protein,Wnt3a,YAP1,YAP1 (phospho S127),YKL-40/CHI3L1,ZAP70,ZEB1
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服务货号:
LXDSPH72-IPA
交付周期:
需咨询
价格:
¥199,943.00/芯片,72个AOI
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- 产品介绍
- 技术平台介绍
产品介绍
检测指标: 点击检测指标名称可查看该指标具体功能介绍
技术平台介绍
近年来,随着生物技术和分析方法的不断进步,定量蛋白质和基因水平的研究在理解疾病机制和寻找治疗靶点等领域扮演着至关重要的角色。此外,深入了解组织生物学也需要考虑到空间维度的因素,因此空间分析在该领域的发展备受关注。Nature Methods杂志将空间多组学技术列为2022年最令人期待的七项技术之一,目前已有多家企业推出了空间多组学技术的商业化产品,有助于研究人员探索空间转录组的奥秘。
Nanostring GeoMx DSP技术提供结合了组织影像分析技术和高通量分子定量技术,能够在组织切片原位实现多靶标蛋白和全转录组的空间原位表达谱分析。通过捕获具有形态学背景的图像,按照组织形态、表型、单个细胞、按网格或者绘制区域轮廓,研究者可以选择感兴趣的区域进行分析。
DSP 空间多组学实验全流程
1、标记荧光抗体与待测指标共孵育:一张5μm厚度的切片同时用成像试剂(荧光标记的抗体/探针)和定量试剂(Oligo标记抗体/探针)混合杂交
2、ROI区域圈选:可以选择任何区域,任何形状和大小的ROI
3、区域划分&紫外光解DSP Barcode:每个圈选的目标区域依次被紫外光照射,并切断定量试剂上偶联的Oligo序列。在不接触样本的情况下,用微毛细管快速吸出解离的Oligo序列,使样本切片完整。
4、逐个ROI收集DSP Barcode到96孔板: Oligo标签被收集到96孔收集板中,每一个孔对应组织切片上选择的一个ROI/AOI。
5、Barcode计算、测序和数据分析:收集的Oligo利用高通量测序(NGS)或 在NanoString的nCounter平台上进行定量。
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