Introduction:This study aimed to explore the association between plasma amyloid-β oligomerization tendency (OAβ) and cognitive performance in Alzheimer's disease (AD) and determine its predictive value for outcomes of mild cognitive impairment (MCI).
Methods:Plasma from 727 subjects (286 AD, 260 MCI, and 181 controls) in a case registry was analyzed using the multimer detection system (MDS) to measure plasma OAβ.
Results:Elevated plasma OAβ was strongly correlated with multidomain cognitive performance in patients with MCI and AD. Patients with MCI with high baseline plasma OAβ demonstrated a higher risk of progressing to dementia (hazard ratio = 1.083, 95% confidence interval [CI] 1.032-1.137). Baseline plasma OAβ effectively predicted MCI-dementia conversion (area under the curve [AUC] = 0.824, 95% CI 0.752-0.897).
Discussion:The real-world findings underscore the clinical relevance of plasma OAβ as a potential predictor for the conversion from mild cognitive impairment (MCI) to dementia.
Highlights:We recruit study participants of Alzheimer's dementia (AD), mild cognitive impairment (MCI), and cognitively normal controls in a case registry.We use the multimer detection system (MDS) to measure plasma amyloid-β oligomerization tendency (OAβ).We observe that elevated plasma OAβ strongly correlates with multidomain cognitive performance in patients with MCI and AD.MCI individuals with high baseline plasma OAβ demonstrate a higher risk of progressing to dementia.The real-world findings underscore the clinical relevance of plasma Oaβ as a potential predictor for the conversion from MCI to dementia.
Keywords:Alzheimer's disease; amyloid; biomarker; mild cognitive impairment; oligomerization.

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乐备实（上海优宁维生物科技股份有限公司旗下全资子公司），是国内专注于提供高质量蛋白检测以及组学分析服务的实验服务专家，自2018年成立以来，乐备实不断寻求突破，公司的服务技术平台已扩展到单细胞测序、空间多组学、流式检测、超敏电化学发光、Luminex多因子检测、抗体芯片、PCR Array、ELISA、Elispot、PLA蛋白互作、多色免疫组化、DSP空间多组学等30多个，建立起了一套涵盖基因、蛋白、细胞以及组织水平实验的完整检测体系。

 
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