Characterization of pro-inflammatory flagellin proteins produced by Lactobacillus ruminis and related motile Lactobacilli

Cytokines;Chemokines;细胞因子;趋化因子;MSD;Cytokines;Chemokines
浏览次数:32 分享:

Neville BA, Forde BM, Claesson MJ, Darby T, Coghlan A, Nally K, Ross RP, O’Toole PW.

  • PLoS One
  • 2012
  • 3.041
  • 7(7):e40156.
  • Canine,Human,Non-Human Primate
  • MSD
  • Cell culture supernatants
  • 免疫/内分泌
  • 其它细胞
  • IL-8

相关货号

LXMH04-2LXMH04-4LXMH07-4LXMH09-1LXMH09-3LXMH10-1LXMH10-3LXMH10-9LXMH11-1LXMH111-1LXMH13-1LXMH30-1LXMH37-1LXMH40-1LXMH44-1LXMH46-1LXMH54-1LXMH71-1LXMH87-1LXMN03-1LXMN05-1LXMN06-1LXMN06-3LXMN09-2LXMN09-4LXMN10-1LXMN10-2LXMN24-2LXMN61-1

Abstract

Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that potentiates glucose-stimulated insulin secretion during a meal. Since GIP has also been shown to exert β-cell prosurvival and adipocyte lipogenic effects in rodents, both GIP receptor agonists and antagonists have been considered as potential therapeutics in type 2 diabetes (T2DM). In the present study, we tested the hypothesis that chronically elevating GIP levels in a transgenic (Tg) mouse model would increase adipose tissue expansion and exert beneficial effects on glucose homeostasis. In contrast, although GIP Tg mice demonstrated enhanced β-cell function, resulting in improved glucose tolerance and insulin sensitivity, they exhibited reduced diet-induced obesity. Adipose tissue macrophage infiltration and hepatic steatosis were both greatly reduced, and a number of genes involved in lipid metabolism/inflammatory signaling pathways were found to be down-regulated. Reduced adiposity in GIP Tg mice was associated with decreased energy intake, involving overexpression of hypothalamic GIP. Together, these studies suggest that, in the context of over-nutrition, transgenic GIP overexpression has the potential to improve hepatic and adipocyte function as well as glucose homeostasis.
金课堂之文献解析 文献原文请点击

技术文章 更多

    研究领域 更多

      热点文献