Tobacco smoke exposure and altered nasal responses to live attenuated influenza virus

Cytokines;Chemokines;细胞因子;趋化因子;MSD;Cytokines;Chemokines
浏览次数:20 分享:

Noah, T.L., Zhou, H., Monaco, J., Horvath, K., Herbst, M., Jaspers, I.

  • Environ Health Perspect.
  • 2011
  • 11.035
  • 83(4):884-90.
  • Human,Mouse,Non-Human Primate,Rat
  • MSD
  • Nasal lavage fluid (NLF)
  • 呼吸系统
  • 流感
  • GM-CSF, IL-10, IL-12 p70, IL-2

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LXMH06-1LXMH07-4LXMH09-1LXMH09-2LXMH09-3LXMH10-3LXMH10-4LXMH10-5LXMH10-9LXMH111-1LXMH14-1LXMH44-1LXMH46-1LXMH54-1LXMH71-1LXMH87-1LXMM08-1LXMM14-1LXMM50-1LXMM58-1LXMN05-1LXMN06-3LXMN09-2LXMN09-3LXMN09-4LXMN10-3LXMN12-1LXMN61-1

Abstract

Lymphatic dilatation, dysfunction, and lymphangiogenesis are hallmarks of patent lymphatic filariasis, observed even in those with subclinical microfilaremia, through processes associated, in part, by vascular endothelial growth factors (VEGFs). A panel of pro-angiogenic factors was measured in the plasma of subjects from filaria-endemic regions using multiplexed immunological assays. Compared with endemic normal control subjects, those with both subclinical microfilaremia, and those with longstanding lymphedema had significantly elevated levels of VEGF-A, VEGF-C, VEGF-D, and angiopoietins (Ang-1/Ang-2), with only levels of basic fibroblast growth factor (bFGF) and placental growth factor (PlGF) being elevated only if lymphedema was evident. Furthermore, levels of these factors 1-year post-treatment with doxycycline were similar to pretreatment levels suggesting a minimal role, if any, for Wolbachia. Our data support the concept that filarial infection per se is associated with elevated levels of most of the known pro-angiogenic factors, with only a few being associated with the serious pathologic consequences associated with Wuchereria bancrofti infection.
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