Single cell sequencing reveals heterogeneity within ovarian cancer epithelium and cancer associated stromal cells

cancer;癌症;肿瘤;单细胞测序;单细胞多组学
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Boris J Winterhoff, Makayla Maile, Amit Kumar Mitra, Attila Sebe, Martina Bazzaro, Melissa A Geller, Juan E Abrahante, Molly Klein, Raffaele Hellweg, Sally A Mullany, Kenneth Beckman, Jerry Daniel, Timothy K Starr

  • Gynecol Oncol
  • 2017
  • 5.304
  • 144(3):598-606.
  • Human
  • 单细胞测序
  • Cancer stem cell
  • 生殖系统
  • 上皮细胞
  • 卵巢癌
  • ABCG2, AL1A1, AL1A2, AL1A3, CD24, CD44, EPCAM, KIT, MYD88, PROM1
  • UBERON_0000992

Abstract

Objectives: The purpose of this study was to determine the level of heterogeneity in high grade serous ovarian cancer (HGSOC) by analyzing RNA expression in single epithelial and cancer associated stromal cells. In addition, we explored the possibility of identifying subgroups based on pathway activation and pre-defined signatures from cancer stem cells and chemo-resistant cells.
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