Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing

single cell sequencing;SNS;单细胞测序;单细胞多组学
浏览次数:120 分享:

Shuai Gao, Liying Yan, Rui Wang, Jingyun Li, Jun Yong, Xin Zhou, Yuan Wei, Xinglong Wu, Xiaoye Wang, Xiaoying Fan, Jie Yan, Xu Zhi, Yun Gao, Hongshan Guo, Xiao Jin, Wendong Wang, Yunuo Mao, Fengchao Wang, Lu Wen, Wei Fu, Hao Ge, Jie Qiao, Fuchou Tang

  • Nat Cell Biol
  • 2023
  • 28.213
  • Human
  • 单细胞测序
  • Ciliated epithelial cell
  • 技术分享
  • 上皮细胞
  • SYAM, ABCAD, ABCBA, ADAP1, ADGB, NA, CBPC2, CBPC5, KAD8, KAD9, AKA28, A16A1, AL1A1, AL3B1, ALMS1, ANKY1, AN18A, ANR54, ANR66, ANKUB, AP3M2, APBB2, APCD1, APH1B, RHG18, RHG39, ARHGB, ARH38, AR13B, ARMC2, ARMC3, CI037, ASIC1, ASTN2, ATAT, AT2C2, VPP4, VATC2, ATX2, B9D1, BAIP3, BASP1, BBS1, BBS5, BCAS3, BHLH9, BPIB1, BTC, NA, CK016, CK070, CK088, CL076, CP046, NA, CA194, CA087, CT085, CT096, C2C2L, AUGN, CB070, CB081, CC067, CD022, CD047, C5AR1, CE042, CE049, CF118, CG057, CH034, CI135, NA, CCG6, CAYP2, CAPSL, CASC1, CC103, CC114, CCD13, CC148, CC157, CC170, CC173, CC181, CCD24, CCD33, CCD39, CCD60, DRC2, CC74A, CC74B, CCD78, CCD81, DAPLE, C16L2, CD38, CDHR3, CDHR4, CDS1, CEBPA, CE162, CEP97, EST1, EST4A, FLTOP, PCDP1, CFA43, CFA44, CFA46, CFA47, CFA52, CFA53, CFA54, CFA57, CFA61, CFA69, PROP, CHSTB, CHST9, CLD16, CO4A5, CERU, CPEB1, CROCC, CSMD1, CSPP1, CYTM, CTGF, CXXC4, DALD3, DCDC1, DCDC2, DCDC5, DCP1B, DGCR6, DHRS9, DLEC1, DMPK, DAAF1, DYH1, DYH10, DYH11, DYH12, DYH5, DYH6, DYH7, DYH9, DNAI1, DNAI2, DNAL1, DPCD, D19L1, D19L2, D19P2, DRC1, DTHD1, DTNA, DYDC2, DYHC2, NA, DZI1L, DZIP3, ECT2L, EFCB1, EFC10, EFHB, EFHC1, EFHC2, NUCG, ENPP4, ENPP5, NA, ERBB4, ERIC2, FABP6, F174A, NA, F183A, F227A, FA81B, FA92B, FBX15, FBX31, FBX36, FGF14, FR1OP, FHAD1, NA, FRPD2, GALC, GALNS, GA2L2, DRC4, GRAN, CXA4, GLB1L, NA, GGA2B, NA, NA, HHLA2, HRSL2, HYDIN, IFT46, IFT57, IFT80, IFT81, IFT88, IKZF4, I20RA, IL5RA, I5P2, NA, DRC11, DRC10, IQCH, IQUB, ITAL, ITGBL, KTNB1, KCNB1, KCNE1, KCMB2, KCNRG, K0754, K1257, NA, K2012, KIF17, KIF19, KIF27, KIF3A, KIF6, KIF9, NA, KLDC9, KLH32, KNDC1, KSR1, LRAD1, LGR4, NA, LKAM1, LMLN, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, LRIG1, LR10B, LRC23, LRC27, LRC46, LRC61, LRC71, LR74B, LRIQ1, LRWD1, LTBP1, LZTL1, CFA91, MAP9, MK15, MARE3, NA, METK1, MYG, MDH1B, MDM1, NA, MLF1, ENL, MELPH, MOB1B, MORN2, MORN3, MPDZ, MLN, M4A8, NBEA, NEK10, NEK5, NELL2, NHLC4, NOVA1, NPHP1, NPIA1, NRP2, NWD1, NXF3, ODF3B, NA, OSGEP, OTUD1, OXYR, P4HTM, PACRG, PECR, PROF2, PHTF1, PIHD2, PLCB2, PLCG2, PKHS1, PNO1, DPOLQ, PPR36, PPR42, PRIC2, NA, PRR29, PRUN2, PEN2, NA, PTPRT, PTH, NA, PZP, TGT, RBL2A, RBL2B, RAE1E, RARB, RASA3, RBM38, RGS22, RHPN1, RIBC1, RIBC2, RIAD1, RITA1, RNAS4, RNLS, ROP1L, FTM, RAD, RSPH1, RSH4A, RSPH9, RUVB1, SAM15, SAXO2, SG2A1, SDF2L, SMS2, SHAN2, SIAH3, S12A7, S13A3, S22AG, S22AI, MCATL, S27A2, S41A1, CTL4, SC6A9, CTR2, SL9A4, NSMA, NSMA2, NA, SNTAN, SNX13, SNX29, SNX7, SP17, SPAG1, SPG17, SPAG6, SPAG8, SPT17, MIEAP, SPAT4, SPA6L, SPAS1, SPEF1, SPEF2, SSBP4, SSUH2, SIA7B, STK33, STMD1, STML3, STX2, STX7, SVOPL, SYBU, SYNE1, SYT10, SYTL3, TBC31, TC1D1, TECT1, TEKT2, TEKT3, TEKT4, TFF3, TGM3, T10B, TMC5, T151B, TM190, TM231, TM232, TM234, TM45B, MKS3, TNR19, P73, TRI37, TRM1, TRPC1, TXIP1, TSN15, TSN19, TTC16, TT21A, TT23L, TTC25, IFT56, TT30A, TTLL6, TTLL7, TTLL9, TBA4B, TXD11, UBE3D, UBX10, UBX11, UBP2, UBP24, UBP51, VWA3A, VWA3B, SYWC, NA, WDR19, WDR38, WDR54, WDR5B, WDR63, WDR78, WDR90, WFDC3, WNT16, ZBBX, ZBED4, NA, ZMY10, ZMY12, ZN273, ZN322, ZN440, ZN674, ZN688
  • UBERON_0001043

Abstract

The development of the digestive tract is critical for proper food digestion and nutrient absorption. Here, we analyse the main organs of the digestive tract, including the oesophagus, stomach, small intestine and large intestine, from human embryos between 6 and 25 weeks of gestation as well as the large intestine from adults using single-cell RNA-seq analyses. In total, 5,227 individual cells are analysed and 40 cell types clearly identified. Their crucial biological features, including developmental processes, signalling pathways, cell cycle, nutrient digestion and absorption metabolism, and transcription factor networks, are systematically revealed. Moreover, the differentiation and maturation processes of the large intestine are thoroughly investigated by comparing the corresponding transcriptome profiles between embryonic and adult stages. Our work offers a rich resource for investigating the gene regulation networks of the human fetal digestive tract and adult large intestine at single-cell resolution.
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