Cerebrospinal fluid regulates skull bone marrow niches via direct access through dural channels

脑淀粉样;血管病变

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Jose A Mazzitelli #, Leon C D Smyth #, Kevin A Cross, Taitea Dykstra, Jerry Sun, Siling Du, Tornike Mamuladze, Igor Smirnov, Justin Rustenhoven, Jonathan Kipnis

期刊 Nat Neurosci
影响因子 28.771
起止号 25(5):555-560.
种属 Mouse
技术平台 Luminex
研究方向生物标志物
检测蛋白 Eotaxin/CCL11,G-CSF,GM-CSF,IFN-γ,IL-10,IL-12(p40),IL-12(p70),IL-13,IL-17A,IL-1α,IL-1β,IL-2,IL-3,IL-4,IL-5,IL-6,IL-9,GRO-α (Gro-a/KC/CXCL1),MCP-1/CCL2,MIP-1α/CCL3,MIP-1β,RANTES,TNF-α

Abstract

It remains unclear how immune cells from skull bone marrow niches are recruited to the meninges. Here we report that cerebrospinal fluid (CSF) accesses skull bone marrow via dura-skull channels, and CSF proteins signal onto diverse cell types within the niches. After spinal cord injury, CSF-borne cues promote myelopoiesis and egress of myeloid cells into meninges. This reveals a mechanism of CNS-to-bone-marrow communication via CSF that regulates CNS immune responses.

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Abstract