1600种自免和肿瘤抗原-单色
浏览次数:3011 分享:
A1BG,AAK1,AARS,ABCF1,ABCF3,ABI1,ABL2,ABT1,ACAT2,ACPP,ACRBP,ACSL6,ACTA1,ACTB,ACTL7B,ACTL8,ACTR2,ACVR1,ACVR1C,ACVR2A,ADAM2,ADAM29,ADCK1,ADD1,ADSL,AFF4,AFP,AGR2,AHSG,AICDA,AIF1,AIFM2,AIFM3,AIM2,AK1,AK2,AK3,AK4,AK7,AK9,AKAP3,AKAP4,AKT1,AKT3,ALDOA,ALOX15,ALOX15B,ALPK1,ALX1,AMD1,AMOTL2,AMT,ANKRD13A,ANKRD45,ANXA1,ANXA11,ANXA2,AP2M1,APCS,APEX1,API5,APOBEC3G,APP,APPL1,AR,ARAF,AREG,ARHGDIA,ARHGDIB,ARHGDIG,ARIH2,ARL1,ARMC3,ARNT,ARRB1,ARX,ASB1,ASCL1,ASNA1,ASPSCR1,ATF1,ATF2,ATF3,ATF4,ATF5,ATG12,ATG7,ATIC,ATP5B,ATXN3,AURKA,AURKB,AXIN1,AXL_int,BACH1,BAD,BAG3,BAG4,BAGE2,BANK1,BASP1,BATF,BCKDK,BCL10,BCL2A1,BCL2L14,BDNF,BID,BIRC2,BIRC3,BIRC5,BIRC7,BLK,BLZF1,BMP7,BMPR1A,BMPR1B,BMPR2,BMX,BOLA3,BOP1,BPI,BPIFA1,BRAF,BRD2,BRD3,BRD8,BRDT,BRSK1,BRSK2,BTF3,BTG1,BTG3,BTRC,BUB1,BUB1B,BUD31,C1D,C1orf174,C1orf216,C21orf2,C21orf33,C4BPA,C6,C6orf106,CA1,CA4,CA9,CAB39L,CABYR,CAGE1,CALM2,CALM3,CALML4,CALR,CALR3,CALU,CAMK1,CAMK1G,CAMK2A,CAMK2B,CAMK2D,CAMK2G,CAMK4,CAMKK1,CAMKK2,CAMKV,CAPG,CARD8,CARD9,CARHSP1,CASP1,CASP10,CASP3,CASP4,CASP6,CASP9,CASS4,CBFA2T3,CBFB,CBLC,CBX5,CCDC110,CCDC183,CCDC33,CCDC36,CCM2,CCNA1,CCNA2,CCNB1,CCNB1IP1,CCND1,CCND2,CCNH,CCNI,CCR5,CCT3,CCT5,CD276,CD5L,CD96,CDC20,CDC25A,CDC25C,CDC42,CDH19,CDK1,CDK10,CDK11B,CDK14,CDK16,CDK17,CDK18,CDK19,CDK2,CDK20,CDK3,CDK4,CDK5,CDK5R1,CDK7,CDK8,CDK9,CDKN1A,CDKN2A,CDKN2B,CDKN2C,CDKN2D,CDO1,CEACAM1,CEACAM7,CEACAM8,CEBPG,CEP55,CERS2,CFL1,CHEK1,CHEK2,CHI3L1,CHIC2,CHMP3,CHN1,CHST4,CIDEB,CIDEC,CISH,CITED1,CKB,CKM,CKMT2,CKS1B,CLK1,CLK2,CLK3,CLUAP1,CMC4,CMPK1,CNN1,CNOT2,CNOT8,CNOT9,CNRIP1,COL4A3BP,COMMD3,COPG2,COPS6,COQ8A,COQ8B,COTL1,COX6B2,COX6C,CPA4,CPM,CPXCR1,CRADD,CREB1,CREB5,CRISP2,CROT,CRX,CRYAB,CSAG1,CSAG2,CSK,CSNK1D,CSNK1G1,CSNK1G2,CSNK2A1,CSNK2A2,CSRNP1,CST4,CSTB,CT45A1,CT47A1,CT55,CT62,CT83,CTAG1A,CTAG2,CTAGE1,CTAGE5,CTBP2,CTCFL,CTNNA2,CTNNB1,CTNNBL1,CTSD,CTSE,CTTN,CUL4A,CUL5,CWC27,CXCR2,CXCR4,CXCR6,CXXC1,CYCS,CYLD,CYP1B1,DAPK1,DAPK2,DBNL,DCAF12,DCBlD2,DCDC2,DCLK1,DCLK2,DCT,DDB1,DDB2,DDIT3,DDR1,DDR1_ext,DDR1_int,DDX43,DDX5,DDX53,DDX55,DEDD,DEK,DFFA,DGKA,DGUOK,DKK1,DKKL1,DLX1,DLX3,DLX4,DMAP1,DMPK,DMRTB1,DMRTC2,DNAJA1,DNAJA2,DNAJB1,DNM1L,DNM2,DNMT3L,DNTT,DPF2,DPPA2,DR1,DRD2,DSTYK,DTYMK,DUSP10,DUSP11,DUSP12,DUSP13,DUSP14,DUSP18,DUSP4,DUSP6,DVL2,DXO,DYNC1LI2,DYRK2,DYRK3,DYRK4,E2F6,E6,E7,EAPP,ECI2,EEF1A1,EEF1A2,EEF1D,EEF1G,EEF2K,EFHD2,EFS,EGFR_ext,EGFR_int,EGR2,EHF,EHMT2,EIF4A2,EIF4A3,EIF4E,EIF4EBP1,ELF1,ELF2,ELF4,ELF5,ELK1,ELK3,ELL3,ELMOD1,ELMOD3,ELOA,ELOVL4,ENO1,ENO2,EPAS1,EPCAM,EPHA10,EPHA2,EPHA3_ext,EPHB3_int,EPHB4,EPPIN,EPS15,ERBB2,ERBB3_ext,ERBB3_int,ERCC2,ERCC3,ERCC5,ERG,ESR2,ESRRG,ETNK2,ETS2,ETV4,ETV6,ETV7,EWSR1,EXOSC10,EXOSC4,EXOSC8,EXT1,EXT2,EZH2,EZR,FADD,FAF1,FAIM,FAM133A,FAM46D,FAM50B,FANCC,FAP,FAS,FASTK,FASTKD1,FBXO9,FEN1,FES,FGF1,FGF13,FGFR1,FGFR1_ext,FGFR1_int,FGFR1OP,FGFR2,FGFR2_ext,FGFR2_int,FGFR4_ext,FGFR4_int,FH,FIP1L1,FKBP1B,FKBP3,FKBP5,FLCN,FLI1,FLT1,FMNL2,FMR1NB,FN3K,FOLH1,FOS,FOSL1,FOSL2,FOXA3,FOXI1,FOXN2,FOXR2,FOXS1,FRK,FSCN1,FTH1,FTHL17,FTSJ3,FUS,FYN,FZD1,G6PD,GADD45G,GAGE1,GAGE2,GALK1,GAPDH,GAS2,GAS7,GATA1,GATA3,GATAD2A,GCLC,GDF15,GEM,GFAP,GGPS1,GIPC1,GK,GK2,GLRX3,GLS2,GMEB1,GMEB2,GMPS,GNA15,GNAI2,GNAI3,GNAO1,GNAZ,GNB1,GNB3,GNG11,GNG2,GNG3,GNG4,GNGT2,GOT1,GP2,GPA33,GPAT2,GPATCH2,GPC3,GPHN,GPX1,GRAP2,GRB10,GRB2,GRB7,GRK2,GRK3,GRK5,GRK6,GRM3,GSK3B,GSTT1,GTF2A2,GTF2B,GTF2E2,GTF2F1,GTF2F2,GTF2H1,GTF2H2C,GTPBP1,GUK1,H2AFY,HAGH,HAGHL,HAND1,HBG1,HCFC2,HCLS1,HDAC1,HDAC3,HDAC4,HES6,HEXIM1,HEYL,HIF1A,HIF3A,HINFP,HIPK1,HIPK4,HIST1H1C,HIST1H4A,HK2,HLX,HMG20B,HMGB2,HMGN5,HNF1B,HNRNPA2B1,HNRNPUL1,HOMER2,HOOK1,HOPX,HORMAD1,HOXA1,HOXA9,HOXB13,HOXB6,HOXB7,HOXC10,HOXC8,HPCAL1,HPRT1,HRAS,HRH1,HRH2,HSBP1,HSF1,HSFY1,HSP90AA1,HSP90AB1,HSPA1A,HSPA5,HSPB8,HSPB9,HSPD1,HSPE1,HTATIP2,HTR1D,HTR2B,HUS1,ID1,ID2,IDI1,IDO1,IFI16,IFI35,IFIT1,IFIT5,IFITM1,IGF2,IGF2BP1,IGF2BP3,IGHG1,IGSF11,IKBKB,IKBKE,IKZF1,IKZF3,IL13RA1,IL13RA2,IL18,IL1A,IL1B,IL1F5,IL1RN,IL21R,IL24,IL37,ILF2,ILK,IMP3,IMPA1,IMPDH1,INA,ING4,INHBA,INPP1,INPP5B,IP6K1,IP6K2,IPMK,IRAK1,IRAK4,IRF4,IRF5,ISG20,IST1,ITGB6,ITGBL1,ITK,ITPK1,ITPKB,JADE1,JAK3,JUNB,JUP,KAT2A,KAT7,KATNB1,KCMF1,KCNIP3,KIF9,KIT,KIT_ext,KIT_int,KLF10,KLF12,KLF4,KLF6,KLF7,KLHL12,KLK3,KRAS,KRT14,KRT15,KRT19,KRT4,KRT8,KXD1,L3MBTL2,LAD1,LAMTOR3,LASP1,LATS1,LCK,LCP1,LDB1,LDB2,LDHA,LDHB,LDHC,LEF1,LEMD1,LGALS1,LGALS7,LGMN,LHFP,LIMK2,LIMS1,LIN28A,LIPI,LMNA,LMO2,LNX1,LRRFIP2,LSM1,LTA4H,LTV1,LUZP4,LY6K,LY86,LY96,LYL1,LYN,LYPD6B,LZTR1,MAEL,MAFG,MAGEA10,MAGEA4,MAGEB1,MAGEB2,MAGEB3,MAGEB4,MAGEB5,MAGEB6,MAGEC1,MAGEC2,MAGEC3,MAK,MAL,MALL,MAP2K1,MAP2K3,MAP2K5,MAP2K6,MAP2K7,MAP3K13,MAP3K14,MAP3K2,MAP3K20,MAP3K6,MAP3K7,MAP4,MAP4K3,MAP4K5,MAPK1,MAPK10,MAPK11,MAPK12,MAPK13,MAPK14,MAPK3,MAPK6,MAPK7,MAPK8_tv1,MAPK8_tv2,MAPK9,MAPKAPK3,MAPKAPK5,MARK2,MARK3,MARK4,MAST1,MASTL,MATK,MATN3,MAX,MAZ,MCM5,MCMBP,MDM2,ME2,MECP2,MED16,MED17,MED21,MED22,MED24,MED30,MED4,MEF2A,MEF2C,MEIS2,MEIS3,MEOX2,METTL3,MIF,MITF,MKNK1,MKNK2,MLANA,MLF1,MLH1,MLKL,MLLT11,MLLT3,MLLT6,MLPH,MLX,MMP11,MMP14,MMP2,MMP24,MNAT1,MNDA,MOB3A,MOK,MORC1,MPP1,MPP3,MPP5,MPZL2,MRPL45,MRPL55,MRPS26,MRPS30,MRT4,MSC,MSH2,MSLN,MSN,MTERF1,MTMR2,MTO1,MUSK,MUTYH,MX1,MX2,MYBL2,MYC,MYCBP,MYCBPAP,MYCL,MYCN,MYD88,MYF6,MYNN,MYOG,MYOZ2,NAB1,NAE1,NAGK,NAP1L1,NAP1L3,NAP1L4,NCK1,NCOA4,NCOA5,NDE1,NDRG1,NDRG2,NDUFAB1,NDUFV3,NEDD9,NEK11,NEK3,NEK7,NELFE,NEUROD1,NEUROD4,NF2,NFATC4,NFE2,NFE2L2,NFIA,NFIB,NFIL3,NFKBIA,NFX1,NFYA,NFYB,NHLH1,NICN1,NIM1K,NKX2-5,NLK,NLRP2,NLRP4,NME4,NME5,NME6,NME7,NME8,NMRAL1,NOL4,NPM1,NPY5R,NR0B2,NR1D2,NR1H2,NR1I2,NR2C1,NR2C2,NR2E1,NR2E3,NR3C1,NR4A1,NR4A2,NR6A1,NRAS,NRBF2,NRBP2,NRF1,NRIP1,NRIP3,NSF,NTPCR,NTRK3_ext,NUAK2,NUBP2,NUCB1,NUDT2,NUF2,NUP50,NXF2,NXF2B,OAS2,ODC1,ODF1,ODF2,ODF3,OGG1,OIP5,OLIG3,OSBPL9,OTOA,OVOL1,OXSR1,P3H4,P4HB,PABPC1,PACSIN3,PAGE1,PAGE2B,PAGE5,PAK2,PAK4,PAK5,PAK6,PANK3,PAPSS2,PASD1,PATZ1,PAX3,PAX5,PAX8,PBX1,PBX3,PC,PCBD1,PCBP2,PCGF2,PCK2,PCLAF,PDCD2L,PDCD5,PDCD6,PDCL3,PDE4A,PDGFB,PDGFRA_ext,PDGFRB,PDGFRB_ext,PDGFRL,PDIK1L,PDK1,PDK2,PDK3,PDK4,PDPK1,PDXK,PEBP1,PELO,PFKFB3,PFKFB4,PFKP,PFN2,PHB2,PHF1,PHF11,PHF5A,PHF7,PHIP,PHKG1,PHKG2,PHLDA1,PHLDA2,PHTF1,PI42B,PIAS2,PIDD1,PIK3C3,PIK3R1,PIM1,PIM2,PIN1,PIP,PIP4K2C,PIP5K1B,PIR,PITRM1,PITX2,PIWIL2,PKDCC,PKLR,PKM,PKMYT1,PKNOX1,PLAC1,PLAGL2,PLD2,PLEKHA5,PLK1,PLK2,PLK4,PMEL,PMF1,PMVK,PNPT1,PO2F2,POLR2I,POMK,POTEE,POTEH,POU2AF1,POU5F1,PPARD,PPARG,PPIC,PPID,PPM1A,PPP1CB,PPP1R14A,PPP1R2P9,PPP2CB,PPP2R1A,PPP2R1B,PPP2R2B,PPP2R2C,PPP2R5A,PPP2R5C,PPP3CA,PPP3CC,PPP3R1,PPP4C,PPP4R1,PQBP1,PRAME,PRC1,PRCC,PRDM4,PRDX1,PRDX6,PRELID1,PRKAA1,PRKAA2,PRKACA,PRKACB,PRKACG,PRKAG3,PRKAR1A,PRKCB,PRKCH,PRKCI,PRKCZ,PRKD2,PRKD3,PRKRA,PRKX,PRL,PRM1,PRM2,PRPF4,PRPS2,PRSS50,PRSS54,PSCA,PSG1,PSG11,PSIP1,PSMA6,PSMB10,PSMB3,PSMB8,PSMB9,PSMD4,PSMD9,PSME1,PSME2,PSME3,PTEN,PTGDR,PTGER3,PTK2_iso1,PTK2_iso2,PTK6,PTK7_ext,PTK7_int,PTP4A1,PTP4A2,PTP4A3,PTPA,PTPN1,PTPN11,PTPN2,PTPN20,PTPN22,PTPN4,PTPN6,PTRH1,PTTG1IP,PXK,PXN,PYCR1,PYGB,PYGO2,RAB38,RABEP1,RABL6,RAC1,RAC2,RAD21,RAD23A,RAD23B,RAD51,RAD51B,RAD51D,RAF1,RAG1,RALBP1,RAN,RAP1GDS1,RAPGEF4,RARA,RARB,RB1,RBKS,RBM28,RBM46,RBM6,RBM7,RBMS1,RBPJ,RCAN1,RCC2,REG3A,RERG,RET,RET_ext,RET_int,REXO4,RFK,RFX3,RGS5,RHOA,RHOB,RHOH,RHOT2,RHOXF2,RIDA,RING1,RIOK2,RIOK3,RIPK1,RIPK2,RNASEL,RNF38,RNF40,RNF6,RNF7,RNGTT,ROPN1,RORC,RPA2,RPL10,RPL10A,RPL11,RPL13A,RPL15,RPL17,RPL18,RPL18A,RPL22,RPL27A,RPL30,RPL31,RPL32,RPL34,RPL37A,RPL5,RPL7A,RPLP1,RPS15A,RPS2,RPS27A,RPS6KA1,RPS6KA2,RPS6KA3,RPS6KA4,RPS6KA5,RPS6KA6,RPS6KB1,RPS6KB2,RPS6KL1,RPS7,RRAGC,RRAS,RRAS2,RTFDC1,RUFY1,RUNX1T1,RUVBL1,RXRB,S100A6,S100A7,S100A8,S100A9,S100P,SAGE1,SAV1,SBDS,SCAND1,SCEL,SCFD1,SCGB1D2,SCMH1,SCP2,SCYL3,SDCCAG3,SDCCAG8,SDHB,SDHC,SEC14L2,SECISBP2,SEMG1,SEPTIN4,SEPTIN5,SEPTIN6,SEPTIN9,SERPINB5,SERPINE2,SERPINF2,SET,SFN,SGK1,SGK2,SGK3,SGO1,SGSM3,SH2B1,SH2D1A,SH3BGRL3,SH3GL1,SH3GLB1,SHPK,SIAH1,SIK2,SIVA1,SIX1,SKAP1,SLA,SLA2,SLC25A6,SLCO6A1,SMAD2,SMAD4,SMAD5,SMAD9,SMARCD1,SMN2,SNCA,SNX6,SOCS2,SOCS3,SOCS5,SOCS6,SOD1,SOD2,SORD,SOX10,SOX15,SOX2,SP1,SP110,SP2,SPA17,SPAG4,SPAG9,SPANXN1,SPANXN2,SPANXN4,SPARC,SPARCL1,SPATA19,SPATA25,SPDEF,SPEG,SPG20,SPIB,SPIC,SPO11,SQSTM1,SRM,SRP19,SRPK1,SRPK2,SRPX2,SRSF5,SS18L1,SSB,SSBP4,SSNA1,SSX1,SSX2,SSX2b,SSX3,SSX4,SSX4B,SSX5,SSX7,STAM,STAM2,STAP1,STARD7,STAT1,STAT3,STAT4,STAT5A,STAU1,STIP1,STK10,STK11,STK16,STK17B,STK24,STK25,STK26,STK3,STK32A,STK32B,STK32C,STK33,STK38,STK38L,STK4,STKLD1,STMN1,STRADA,STRADB,STUB1,STYX,STYXL1,SUB1,SUCLA2,SUFU,SUMO2,SUPT20H,SUPT4H1,SYCE1,SYCP1,SYK,TACC1,TACSTD2,TADA2A,TADA3,TAF5L,TAF6L,TAF7L,TAF9,TAGLN,TAOK3,TARDBP,TBC1D2,TBC1D5,TBCB,TBK1,TBL1X,TBPL1,TBX5,TBX6,TCEA2,TCEAL1,TCF12,TCF21,TCF4,TCL1A,TDP2,TDRD1,TDRD3,TDRKH,TEAD2,TEAD3,TEK,TERT,TEX101,TEX14,TFAP4,TFCP2,TFCP2L1,TFDP1,TFDP2,TFDP3,TFE3,TFEB,TFEC,TFG,TFPT,TFRC,TGFBR2,TGIF1,TGIF2,THEG,THRA,THRB,THUMPD1,TIE1_ext,TIE1_int,TIMP3,TIRAP,TK1,TKT,TLK1,TLK2,TLX2,TMEFF1,TMEFF2,TMEM108,TNFAIP6,TNFAIP8,TNFRSF11B,TNIP1,TNK2,TOLLIP,TOM1,TP53,TP53RK,TP63,TP73,TPI1,TPM1,TPM3,TPM4,TPTE,TRAF1,TRAF2,TRAF3IP1,TRAF4,TRAF5,TRAF6,TRAIP,TRIB2,TRIB3,TRIM32,TRIM37,TRIP11,TRMT10C,TROVE2,TSC22D1,TSC22D4,TSG101,TSGA10,TSPY1,TSPY2,TSPY3,TSSK1B,TSSK2,TSSK3,TSSK6,TTBK2,TTF2,TTK,TUBA4A,TUBB,TUBGCP3,TULP2,TWF1,TWF2,TWIST2,TXN2,TXNRD1,TYMS,TYRO3,TYRO3_int,TYRP1,UBA1,UBA3,UBE2I,UBE2Q1,UBE2V1,UBP1,UCHL3,UCKL1,UHMK1,ULK2,ULK4,UQCRC1,USF1,USF2,USH1C,USP10,UTP14A,UXT,VAV1,VAX2,VCL,VDR,VEGFB,VEGFD,VGLL1,VHL,VIM,VPS45,VPS4A,VPS54,VPS72,VRK3,WAS,WDR45B,WDR46,WISP3,WT1,WWOX,WWTR1,XAGE1A,XAGE2,XAGE4,XBP1,XIAP,XYLB,YARS,YEATS4,YTHDF2,YWHAE,YWHAG,ZAP70,ZBTB16,ZBTB25,ZBTB32,ZBTB7B,ZC4H2,ZFP36L1,ZHX2,ZKSCAN1,ZKSCAN3,ZKSCAN4,ZKSCAN5,ZMAT2,ZMAT3,ZMYM2,ZMYND11,ZMYND8,ZNF136,ZNF165,ZNF169,ZNF174,ZNF19,ZNF202,ZNF207,ZNF256,ZNF274,ZNF276,ZNF277,ZNF282,ZNF3,ZNF323,ZNF331,ZNF346,ZNF35,ZNF354A,ZNF37A,ZNF384,ZNF394,ZNF398,ZNF41,ZNF444,ZNF449,ZNF496,ZNF593,ZNF645,ZNF70,ZNHIT3,ZNRD1,ZSCAN12,ZSCAN16,ZSCAN18,ZSCAN21,ZSCAN26,ZSCAN9
服务货号:
LX-OME-SV1-001
交付周期:
需咨询
价格:
¥9,930.00/单个样本
提交意向
收藏
服务货号:
LX-OME-SV1-001
交付周期:
需咨询
价格:
¥9,930.00/单个样本
提交意向
收藏
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A1BGAAK1AARSABCF1ABCF3ABI1ABL2ABT1ACAT2ACPPACRBPACSL6ACTA1ACTBACTL7BACTL8ACTR2ACVR1ACVR1CACVR2AADAM2ADAM29ADCK1ADD1ADSLAFF4AFPAGR2AHSGAICDAAIF1AIFM2AIFM3AIM2AK1AK2AK3AK4AK7AK9AKAP3AKAP4AKT1AKT3ALDOAALOX15ALOX15BALPK1ALX1AMD1AMOTL2AMTANKRD13AANKRD45ANXA1ANXA11ANXA2AP2M1APCSAPEX1API5APOBEC3GAPPAPPL1ARARAFAREGARHGDIAARHGDIBARHGDIGARIH2ARL1ARMC3ARNTARRB1ARXASB1ASCL1ASNA1ASPSCR1ATF1ATF2ATF3ATF4ATF5ATG12ATG7ATICATP5BATXN3AURKAAURKBAXIN1AXL_intBACH1BADBAG3BAG4BAGE2BANK1BASP1BATFBCKDKBCL10BCL2A1BCL2L14BDNFBIDBIRC2BIRC3BIRC5BIRC7BLKBLZF1BMP7BMPR1ABMPR1BBMPR2BMXBOLA3BOP1BPIBPIFA1BRAFBRD2BRD3BRD8BRDTBRSK1BRSK2BTF3BTG1BTG3BTRCBUB1BUB1BBUD31C1DC1orf174C1orf216C21orf2C21orf33C4BPAC6C6orf106CA1CA4CA9CAB39LCABYRCAGE1CALM2CALM3CALML4CALRCALR3CALUCAMK1CAMK1GCAMK2ACAMK2BCAMK2DCAMK2GCAMK4CAMKK1CAMKK2CAMKVCAPGCARD8CARD9CARHSP1CASP1CASP10CASP3CASP4CASP6CASP9CASS4CBFA2T3CBFBCBLCCBX5CCDC110CCDC183CCDC33CCDC36CCM2CCNA1CCNA2CCNB1CCNB1IP1CCND1CCND2CCNHCCNICCR5CCT3CCT5CD276CD5LCD96CDC20CDC25ACDC25CCDC42CDH19CDK1CDK10CDK11BCDK14CDK16CDK17CDK18CDK19CDK2CDK20CDK3CDK4CDK5CDK5R1CDK7CDK8CDK9CDKN1ACDKN2ACDKN2BCDKN2CCDKN2DCDO1CEACAM1CEACAM7CEACAM8CEBPGCEP55CERS2CFL1CHEK1CHEK2CHI3L1CHIC2CHMP3CHN1CHST4CIDEBCIDECCISHCITED1CKBCKMCKMT2CKS1BCLK1CLK2CLK3CLUAP1CMC4CMPK1CNN1CNOT2CNOT8CNOT9CNRIP1COL4A3BPCOMMD3COPG2COPS6COQ8ACOQ8BCOTL1COX6B2COX6CCPA4CPMCPXCR1CRADDCREB1CREB5CRISP2CROTCRXCRYABCSAG1CSAG2CSKCSNK1DCSNK1G1CSNK1G2CSNK2A1CSNK2A2CSRNP1CST4CSTBCT45A1CT47A1CT55CT62CT83CTAG1ACTAG2CTAGE1CTAGE5CTBP2CTCFLCTNNA2CTNNB1CTNNBL1CTSDCTSECTTNCUL4ACUL5CWC27CXCR2CXCR4CXCR6CXXC1CYCSCYLDCYP1B1DAPK1DAPK2DBNLDCAF12DCBlD2DCDC2DCLK1DCLK2DCTDDB1DDB2DDIT3DDR1DDR1_extDDR1_intDDX43DDX5DDX53DDX55DEDDDEKDFFADGKADGUOKDKK1DKKL1DLX1DLX3DLX4DMAP1DMPKDMRTB1DMRTC2DNAJA1DNAJA2DNAJB1DNM1LDNM2DNMT3LDNTTDPF2DPPA2DR1DRD2DSTYKDTYMKDUSP10DUSP11DUSP12DUSP13DUSP14DUSP18DUSP4DUSP6DVL2DXODYNC1LI2DYRK2DYRK3DYRK4E2F6E6E7EAPPECI2EEF1A1EEF1A2EEF1DEEF1GEEF2KEFHD2EFSEGFR_extEGFR_intEGR2EHFEHMT2EIF4A2EIF4A3EIF4EEIF4EBP1ELF1ELF2ELF4ELF5ELK1ELK3ELL3ELMOD1ELMOD3ELOAELOVL4ENO1ENO2EPAS1EPCAMEPHA10EPHA2EPHA3_extEPHB3_intEPHB4EPPINEPS15ERBB2ERBB3_extERBB3_intERCC2ERCC3ERCC5ERGESR2ESRRGETNK2ETS2ETV4ETV6ETV7EWSR1EXOSC10EXOSC4EXOSC8EXT1EXT2EZH2EZRFADDFAF1FAIMFAM133AFAM46DFAM50BFANCCFAPFASFASTKFASTKD1FBXO9FEN1FESFGF1FGF13FGFR1FGFR1_extFGFR1_intFGFR1OPFGFR2FGFR2_extFGFR2_intFGFR4_extFGFR4_intFHFIP1L1FKBP1BFKBP3FKBP5FLCNFLI1FLT1FMNL2FMR1NBFN3KFOLH1FOSFOSL1FOSL2FOXA3FOXI1FOXN2FOXR2FOXS1FRKFSCN1FTH1FTHL17FTSJ3FUSFYNFZD1G6PDGADD45GGAGE1GAGE2GALK1GAPDHGAS2GAS7GATA1GATA3GATAD2AGCLCGDF15GEMGFAPGGPS1GIPC1GKGK2GLRX3GLS2GMEB1GMEB2GMPSGNA15GNAI2GNAI3GNAO1GNAZGNB1GNB3GNG11GNG2GNG3GNG4GNGT2GOT1GP2GPA33GPAT2GPATCH2GPC3GPHNGPX1GRAP2GRB10GRB2GRB7GRK2GRK3GRK5GRK6GRM3GSK3BGSTT1GTF2A2GTF2BGTF2E2GTF2F1GTF2F2GTF2H1GTF2H2CGTPBP1GUK1H2AFYHAGHHAGHLHAND1HBG1HCFC2HCLS1HDAC1HDAC3HDAC4HES6HEXIM1HEYLHIF1AHIF3AHINFPHIPK1HIPK4HIST1H1CHIST1H4AHK2HLXHMG20BHMGB2HMGN5HNF1BHNRNPA2B1HNRNPUL1HOMER2HOOK1HOPXHORMAD1HOXA1HOXA9HOXB13HOXB6HOXB7HOXC10HOXC8HPCAL1HPRT1HRASHRH1HRH2HSBP1HSF1HSFY1HSP90AA1HSP90AB1HSPA1AHSPA5HSPB8HSPB9HSPD1HSPE1HTATIP2HTR1DHTR2BHUS1ID1ID2IDI1IDO1IFI16IFI35IFIT1IFIT5IFITM1IGF2IGF2BP1IGF2BP3IGHG1IGSF11IKBKBIKBKEIKZF1IKZF3IL13RA1IL13RA2IL18IL1AIL1BIL1F5IL1RNIL21RIL24IL37ILF2ILKIMP3IMPA1IMPDH1INAING4INHBAINPP1INPP5BIP6K1IP6K2IPMKIRAK1IRAK4IRF4IRF5ISG20IST1ITGB6ITGBL1ITKITPK1ITPKBJADE1JAK3JUNBJUPKAT2AKAT7KATNB1KCMF1KCNIP3KIF9KITKIT_extKIT_intKLF10KLF12KLF4KLF6KLF7KLHL12KLK3KRASKRT14KRT15KRT19KRT4KRT8KXD1L3MBTL2LAD1LAMTOR3LASP1LATS1LCKLCP1LDB1LDB2LDHALDHBLDHCLEF1LEMD1LGALS1LGALS7LGMNLHFPLIMK2LIMS1LIN28ALIPILMNALMO2LNX1LRRFIP2LSM1LTA4HLTV1LUZP4LY6KLY86LY96LYL1LYNLYPD6BLZTR1MAELMAFGMAGEA10MAGEA4MAGEB1MAGEB2MAGEB3MAGEB4MAGEB5MAGEB6MAGEC1MAGEC2MAGEC3MAKMALMALLMAP2K1MAP2K3MAP2K5MAP2K6MAP2K7MAP3K13MAP3K14MAP3K2MAP3K20MAP3K6MAP3K7MAP4MAP4K3MAP4K5MAPK1MAPK10MAPK11MAPK12MAPK13MAPK14MAPK3MAPK6MAPK7MAPK8_tv1MAPK8_tv2MAPK9MAPKAPK3MAPKAPK5MARK2MARK3MARK4MAST1MASTLMATKMATN3MAXMAZMCM5MCMBPMDM2ME2MECP2MED16MED17MED21MED22MED24MED30MED4MEF2AMEF2CMEIS2MEIS3MEOX2METTL3MIFMITFMKNK1MKNK2MLANAMLF1MLH1MLKLMLLT11MLLT3MLLT6MLPHMLXMMP11MMP14MMP2MMP24MNAT1MNDAMOB3AMOKMORC1MPP1MPP3MPP5MPZL2MRPL45MRPL55MRPS26MRPS30MRT4MSCMSH2MSLNMSNMTERF1MTMR2MTO1MUSKMUTYHMX1MX2MYBL2MYCMYCBPMYCBPAPMYCLMYCNMYD88MYF6MYNNMYOGMYOZ2NAB1NAE1NAGKNAP1L1NAP1L3NAP1L4NCK1NCOA4NCOA5NDE1NDRG1NDRG2NDUFAB1NDUFV3NEDD9NEK11NEK3NEK7NELFENEUROD1NEUROD4NF2NFATC4NFE2NFE2L2NFIANFIBNFIL3NFKBIANFX1NFYANFYBNHLH1NICN1NIM1KNKX2-5NLKNLRP2NLRP4NME4NME5NME6NME7NME8NMRAL1NOL4NPM1NPY5RNR0B2NR1D2NR1H2NR1I2NR2C1NR2C2NR2E1NR2E3NR3C1NR4A1NR4A2NR6A1NRASNRBF2NRBP2NRF1NRIP1NRIP3NSFNTPCRNTRK3_extNUAK2NUBP2NUCB1NUDT2NUF2NUP50NXF2NXF2BOAS2ODC1ODF1ODF2ODF3OGG1OIP5OLIG3OSBPL9OTOAOVOL1OXSR1P3H4P4HBPABPC1PACSIN3PAGE1PAGE2BPAGE5PAK2PAK4PAK5PAK6PANK3PAPSS2PASD1PATZ1PAX3PAX5PAX8PBX1PBX3PCPCBD1PCBP2PCGF2PCK2PCLAFPDCD2LPDCD5PDCD6PDCL3PDE4APDGFBPDGFRA_extPDGFRBPDGFRB_extPDGFRLPDIK1LPDK1PDK2PDK3PDK4PDPK1PDXKPEBP1PELOPFKFB3PFKFB4PFKPPFN2PHB2PHF1PHF11PHF5APHF7PHIPPHKG1PHKG2PHLDA1PHLDA2PHTF1PI42BPIAS2PIDD1PIK3C3PIK3R1PIM1PIM2PIN1PIPPIP4K2CPIP5K1BPIRPITRM1PITX2PIWIL2PKDCCPKLRPKMPKMYT1PKNOX1PLAC1PLAGL2PLD2PLEKHA5PLK1PLK2PLK4PMELPMF1PMVKPNPT1PO2F2POLR2IPOMKPOTEEPOTEHPOU2AF1POU5F1PPARDPPARGPPICPPIDPPM1APPP1CBPPP1R14APPP1R2P9PPP2CBPPP2R1APPP2R1BPPP2R2BPPP2R2CPPP2R5APPP2R5CPPP3CAPPP3CCPPP3R1PPP4CPPP4R1PQBP1PRAMEPRC1PRCCPRDM4PRDX1PRDX6PRELID1PRKAA1PRKAA2PRKACAPRKACBPRKACGPRKAG3PRKAR1APRKCBPRKCHPRKCIPRKCZPRKD2PRKD3PRKRAPRKXPRLPRM1PRM2PRPF4PRPS2PRSS50PRSS54PSCAPSG1PSG11PSIP1PSMA6PSMB10PSMB3PSMB8PSMB9PSMD4PSMD9PSME1PSME2PSME3PTENPTGDRPTGER3PTK2_iso1PTK2_iso2PTK6PTK7_extPTK7_intPTP4A1PTP4A2PTP4A3PTPAPTPN1PTPN11PTPN2PTPN20PTPN22PTPN4PTPN6PTRH1PTTG1IPPXKPXNPYCR1PYGBPYGO2RAB38RABEP1RABL6RAC1RAC2RAD21RAD23ARAD23BRAD51RAD51BRAD51DRAF1RAG1RALBP1RANRAP1GDS1RAPGEF4RARARARBRB1RBKSRBM28RBM46RBM6RBM7RBMS1RBPJRCAN1RCC2REG3ARERGRETRET_extRET_intREXO4RFKRFX3RGS5RHOARHOBRHOHRHOT2RHOXF2RIDARING1RIOK2RIOK3RIPK1RIPK2RNASELRNF38RNF40RNF6RNF7RNGTTROPN1RORCRPA2RPL10RPL10ARPL11RPL13ARPL15RPL17RPL18RPL18ARPL22RPL27ARPL30RPL31RPL32RPL34RPL37ARPL5RPL7ARPLP1RPS15ARPS2RPS27ARPS6KA1RPS6KA2RPS6KA3RPS6KA4RPS6KA5RPS6KA6RPS6KB1RPS6KB2RPS6KL1RPS7RRAGCRRASRRAS2RTFDC1RUFY1RUNX1T1RUVBL1RXRBS100A6S100A7S100A8S100A9S100PSAGE1SAV1SBDSSCAND1SCELSCFD1SCGB1D2SCMH1SCP2SCYL3SDCCAG3SDCCAG8SDHBSDHCSEC14L2SECISBP2SEMG1SEPTIN4SEPTIN5SEPTIN6SEPTIN9SERPINB5SERPINE2SERPINF2SETSFNSGK1SGK2SGK3SGO1SGSM3SH2B1SH2D1ASH3BGRL3SH3GL1SH3GLB1SHPKSIAH1SIK2SIVA1SIX1SKAP1SLASLA2SLC25A6SLCO6A1SMAD2SMAD4SMAD5SMAD9SMARCD1SMN2SNCASNX6SOCS2SOCS3SOCS5SOCS6SOD1SOD2SORDSOX10SOX15SOX2SP1SP110SP2SPA17SPAG4SPAG9SPANXN1SPANXN2SPANXN4SPARCSPARCL1SPATA19SPATA25SPDEFSPEGSPG20SPIBSPICSPO11SQSTM1SRMSRP19SRPK1SRPK2SRPX2SRSF5SS18L1SSBSSBP4SSNA1SSX1SSX2SSX2bSSX3SSX4SSX4BSSX5SSX7STAMSTAM2STAP1STARD7STAT1STAT3STAT4STAT5ASTAU1STIP1STK10STK11STK16STK17BSTK24STK25STK26STK3STK32ASTK32BSTK32CSTK33STK38STK38LSTK4STKLD1STMN1STRADASTRADBSTUB1STYXSTYXL1SUB1SUCLA2SUFUSUMO2SUPT20HSUPT4H1SYCE1SYCP1SYKTACC1TACSTD2TADA2ATADA3TAF5LTAF6LTAF7LTAF9TAGLNTAOK3TARDBPTBC1D2TBC1D5TBCBTBK1TBL1XTBPL1TBX5TBX6TCEA2TCEAL1TCF12TCF21TCF4TCL1ATDP2TDRD1TDRD3TDRKHTEAD2TEAD3TEKTERTTEX101TEX14TFAP4TFCP2TFCP2L1TFDP1TFDP2TFDP3TFE3TFEBTFECTFGTFPTTFRCTGFBR2TGIF1TGIF2THEGTHRATHRBTHUMPD1TIE1_extTIE1_intTIMP3TIRAPTK1TKTTLK1TLK2TLX2TMEFF1TMEFF2TMEM108TNFAIP6TNFAIP8TNFRSF11BTNIP1TNK2TOLLIPTOM1TP53TP53RKTP63TP73TPI1TPM1TPM3TPM4TPTETRAF1TRAF2TRAF3IP1TRAF4TRAF5TRAF6TRAIPTRIB2TRIB3TRIM32TRIM37TRIP11TRMT10CTROVE2TSC22D1TSC22D4TSG101TSGA10TSPY1TSPY2TSPY3TSSK1BTSSK2TSSK3TSSK6TTBK2TTF2TTKTUBA4ATUBBTUBGCP3TULP2TWF1TWF2TWIST2TXN2TXNRD1TYMSTYRO3TYRO3_intTYRP1UBA1UBA3UBE2IUBE2Q1UBE2V1UBP1UCHL3UCKL1UHMK1ULK2ULK4UQCRC1USF1USF2USH1CUSP10UTP14AUXTVAV1VAX2VCLVDRVEGFBVEGFDVGLL1VHLVIMVPS45VPS4AVPS54VPS72VRK3WASWDR45BWDR46WISP3WT1WWOXWWTR1XAGE1AXAGE2XAGE4XBP1XIAPXYLBYARSYEATS4YTHDF2YWHAEYWHAGZAP70ZBTB16ZBTB25ZBTB32ZBTB7BZC4H2ZFP36L1ZHX2ZKSCAN1ZKSCAN3ZKSCAN4ZKSCAN5ZMAT2ZMAT3ZMYM2ZMYND11ZMYND8ZNF136ZNF165ZNF169ZNF174ZNF19ZNF202ZNF207ZNF256ZNF274ZNF276ZNF277ZNF282ZNF3ZNF323ZNF331ZNF346ZNF35ZNF354AZNF37AZNF384ZNF394ZNF398ZNF41ZNF444ZNF449ZNF496ZNF593ZNF645ZNF70ZNHIT3ZNRD1ZSCAN12ZSCAN16ZSCAN18ZSCAN21ZSCAN26ZSCAN9

技术平台介绍

将各种蛋白质有序地固定于滴定板、滤膜和载玻片等各种载体上成为检测用的芯片,然后,用标记了特定荧光抗菌素体的蛋白质或其他成分与芯片作用,经漂将未能与芯片上的蛋白质互补结合的成分洗去,再利用荧光扫描仪或激光共聚焦扫描技术,测定芯片上各点的荧光强度,通过荧光强度分析蛋白质与蛋白质之间相互作用的关系,由此达到测定各种蛋白质功能的目的。

KREXR® 蛋白质折叠技术

Sengenics专利的 KREXR 蛋白质折叠技术能促进功能性蛋白质的表现以建立高密度阵列,进而加速自身抗体生物标志物的发现。它提供了一种简单快速的方法来固定和纯化正确折叠的蛋白质,以供自身抗体检测。

它是如何运作的?

  • 确保只有正确折叠的蛋白质才会固定在阵列表面上
  • 错误折叠的蛋白质会无法附着,并被洗去
  • 固定的蛋白保留其折叠结构,在水凝胶涂层的阵列表面上的表现就如同在游离溶液中一样
  • 如此可确保每项测定均在正确折叠、全长、具功能性的蛋白质上运行,这是基于自身抗体的测定的关键,其中超过90% 的抗体会辨识只有在蛋白质正确折叠时才能取得的构象抗原表位

由于专有的表面化学作用,蛋白质表现就如同在游离溶液中

  • 蛋白质被固定于链霉亲和素包被的水凝胶上
  • 蛋白质在水性环境中保留其经折叠的结构和功能
  • 蛋白质从玻璃表面突出,并附着于单一位点,确保在每个阵列上的方向一致

应用

为不同患者群体发掘自身抗体的力量

分析自身抗体可以更深入地了解患者的免疫状态,为评估疾病和预测治疗结果提供了很大的希望。使用Sengenics蛋白质阵列验证的自身抗体生物标志物,已在早期疾病检测、患者分层、反应预测和伴随诊断方法的开发方面表现出效用。

生物标志物发现与验证

识别自身抗体生物标志物特征

高密度蛋白质微阵列测定法可直接从患者血清中,以高度的特异性和再现性检测出疾病相关自身抗体。

患者分层

疾病内分层、队列识别和临床试验患者富集作用

预测性自身抗体生物标志物特征有助于识别药物应答者和无应答者,以及生物学相关子队列。这些见解能推动更有效率且更经济的试验设计,以及临床试验患者富集作用。

反应预测

预测应答者、无应答者和有不良事件风险者

自身抗体生物标志物可用于建立特征,以预测患者是否可能对治疗产生反应。预测性特征也可用于识别可能发生不良事件的患者群体。

诊断方法与伴随诊断方法(CDx)开发

建立用于伴随诊断方法开发的生物标志物特征

自身抗体在病程的早期出现,可用于建立疾病特定特征,以进行早期检测。自身抗体的特征可在开发伴随诊断方法中扮演重要角色,以确保患者接受正确的治疗。

案例分享

非小细胞肺癌的预测性自身抗体生物标志物检测全项

Kaplan Meier曲线显示在曾接受肺切除术的非小细胞肺癌(NSCLC) 患者中, 13种自身抗体生物标志物特征表达过高和过低的患者的总体生存期。高表达特征的患者表现出较差的生存能力,整体5年生存率为7.6%

Patel, A.J., et al. A Highly Predictive Autoantibody-based Biomarker Panel for Prognosis in Early-stage NSCLC with Potential Therapeutic Implications, British Journal of Cancer (2021).

类风湿性关节炎患者的抗药抗体候选自身抗体生物标志物

用于预测接受adalimumab治疗的类风湿性关节炎患者抗药抗体(ADAb)生成的候选自身抗体生物标志物。是否存在抗药抗体和临床反应的自身抗体存在和分层式集群热图。在基线期和 adalimumab 疗法 24 周后采集的血浆样本。自身抗体浓度是以 RFU 为单位,并以色度表示。

Chen, P., et. al., Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA, Journal of Immunology Research (2021).

系统性红斑性狼疮患者分层

系统性红斑性狼疮 (SLE) 患者中,来自发现 (n = 186) 和验证 (n = 91) 队列的 79 种经验证自身抗体的非监督分层式集群热图。自身抗体集群为四个不同的组别。这些集群可合理地代表 SLE 的不同分子亚型,其具有不同的疾病预测轨迹和不同的治疗反应。

M.J. Lewis, et al., Autoantibodies Targeting TLR and SMAD Pathways Define New Subgroups in Systemic Lupus Erythematosus, Journal of Autoimmunity(2018).

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